Numb is not a critical regulator of Notch-mediated cell fate decisions in the developing chick inner ear
نویسندگان
چکیده
منابع مشابه
Numb is not a critical regulator of Notch-mediated cell fate decisions in the developing chick inner ear
The Notch signaling pathway controls differentiation of hair cells and supporting cells in the vertebrate inner ear. Here, we have investigated whether Numb, a known regulator of Notch activity in Drosophila, is involved in this process in the embryonic chick. The chicken homolog of Numb is expressed throughout the otocyst at early stages of development and is concentrated at the basal pole of ...
متن کاملMastermind critically regulates Notch-mediated lymphoid cell fate decisions.
During lymphoid development, Notch1 plays a critical role in the T-cell/B-cell lineage decision, while Notch2 is essential for marginal zone B-cell (MZB) development. Notch pathway activation induces translocation of intracellular Notch (ICN) to the nucleus, where it interacts with the transcription factor CSL (CBF1/RBP-Jk, Suppressor of Hairless, Lag-1). In vitro, ICN binds Mastermind-like pro...
متن کاملNotch signalling is needed to maintain, but not to initiate, the formation of prosensory patches in the chick inner ear.
Notch signalling is well-known to mediate lateral inhibition in inner ear sensory patches, so as to generate a balanced mixture of sensory hair cells and supporting cells. Recently, however, we have found that ectopic Notch activity at an early stage can induce the formation of ectopic sensory patches. This suggests that Notch activity may have two different functions in normal ear development,...
متن کاملHEMATOPOIESIS Mastermind critically regulates Notch-mediated lymphoid cell fate decisions
During lymphoid development, Notch1 plays a critical role in the T-cell/B-cell lineage decision, while Notch2 is essential for marginal zone B-cell (MZB) development. Notch pathway activation induces translocation of intracellular Notch (ICN) to the nucleus, where it interacts with the transcription factor CSL (CBF1/ RBP-Jk, Suppressor of Hairless, Lag-1). In vitro, ICN binds Mastermind-like pr...
متن کاملThe Mdm2 oncoprotein interacts with the cell fate regulator Numb.
The Mdm2 oncoprotein is a well-known inhibitor of the p53 tumor suppressor, but it may also possess p53-independent activities. In search of such p53-independent activities, the yeast two-hybrid screen was employed to identify Mdm2-binding proteins. We report that in vitro and in transfected cells, Mdm2 can associate with Numb, a protein involved in the determination of cell fate. This associat...
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ژورنال
عنوان ژورنال: Frontiers in Cellular Neuroscience
سال: 2015
ISSN: 1662-5102
DOI: 10.3389/fncel.2015.00074